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Learning • Autism • CP

Neurons and blood vessels within a healthy brain resemble a healthy tree with a fully branched canopy. There's a trunk, a root system and there are the branches, called dendrites. Dendritic arborization, also known as dendritic branching, is a multi-step biological process by which neurons form new dendritic trees and branches to create new synapses.1 A healthy brain will resemble a branched network connecting different parts of the brain to create uninterrupted neural communication. This connected network of synapses seamlessly communicates together to create speech, memory, social interactions, and other aspects of the nervous system. Conversely, imaging from postmortem2 autistic brains reveal neurons and blood vessels that resemble a diseased tree. Injured brains form a network of splitting vascular and neuron branches that create knots from which new branches form. These malformed brain characteristics can also be seen with other neurological conditions like depression, schizophrenia, Down syndrome, and anxiety. Thus, the tree root icon was chosen because the TruDOSE treatment encourages blood vessels and neurons like a healthy tree.

Neural plasticity is a phenomenon that aids brain recovery after the damage produced by events like stroke or traumatic injury. Injury events to the brain typically lead to loss of micro blood vessels and neuron connections. Plasticity can be understood as the body innately manipulating specific neuronal pathways and synapses for therapeutic and clinical interventions that will improve our health. As we age, the brain becomes less plastic and becomes hard wired. This hardwiring diminishes the possibility of neurological improvements in a variety of domains (cognition, fine motor, etc.). However, platelets within the plasma treatment provides a plethora of biological growth factors like brain derived growth factor (BDNF) and Vascular endothelial growth factor (VEGF) that are specifically responsible for creating new blood vessels and new neuron connections. Thus, the TruDOSE therapy potentially serves as a holistic therapy to restore neural plasticity to otherwise injured brains.

1  Richard C. Lewis. 2016. University of Iowa. 

2Azmitia et al. 2016. Persistent angiogenesis in the autism brain:  An immunocytochemical study of postmortem cortex, brainstem and cerebellum

Click below to view conditions associated with these disorders and see how TruDOSE can help.



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